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Bivalirudin Acetate

Name
Bivalirudin Acetate
Molecular Formula
C98H138N24O33
CAS
128270-60-0
Sequence D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH
Molecular Weight 2180.33
Purity (HPLC) 99%min
Appearance White powder
Single Impurity(HPLC) 1%max
Amino Acid Composition ±10% of theoretical
Peptide Content(N%)
≥80.0%
Water Content(KF) ≤8.0%
Acetate Content(HPLC) 12%
MS(ESI)
Consistent
Mass Balance 95.0~105.0%

Bivalirudin directly inhibits thrombin by specifically binding both to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin.
Thrombin is a serine proteinase that plays a central role in the thrombotic process, acting to cleave fibrinogen into fibrin monomers and to activate Factor XIII to Factor XIIIa, allowing fibrin to develop a covalently cross-linked framework which stabilizes the thrombus; thrombin also activates Factors V and VIII, promoting further thrombin generation, and activates platelets, stimulating aggregation and granule release.

Price
500mg USD  
1g USD  
10g USD  
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