Exenatide Acetate (Exendin-4)

Name	Exenatide Acetate; Exendin-4
Molecular Formula	C₁₈₄H₂₈₂N₅₀O₆₀ S
CAS	141758-74-9
Sequence	H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu- Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu- Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser- Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Molecular Weight	4186.66
Purity (HPLC)	98%min
Appearance	White powder
Water Content(KF)	10.0% max
Peptide Content(N%)	80.0% min
Acetate Content(HPLC)	12.0% max
Single Impurity (HPLC)	1.0% max
"Exenatide can be considered an effective treatment option in such patients, including those with high baseline HbA1c and long duration of diabetes". M. Buysschaert et al.: Diabetes & Metabolism 36 (2010) 381–388 "The addition of exenatide to insulin-based therapy was associated with reductions in mean HbA1c' weight, and prandial insulin requirements for treatment periods of up to 27 months, and in total insulin requirements for treatment periods of up to 12 months".Nancy M. Yoon et al.: Clin Ther. 2009;31:1511-1523

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Peptide